It may just be your computer, but have you gone over and compared the specs between your game and computer?
From microsoft.com:
FABLE TLC Minimum requirements:
One of the following Microsoft Windows XP operating systems:
o Microsoft Windows XP Home Edition
o Microsoft Windows XP Professional
o Microsoft Windows XP Media Center Edition
* A computer that has a 1.4 gigahertz (GHz) equivalent or higher processor.
* Microsoft DirectX 9.0 or a later version of Microsoft DirectX. Microsoft DirectX
9.0c is installed by Fable: The Lost Chapters.
* 256 megabytes (MB) of system RAM.
* 3 gigabytes (GB) of available hard disk space.
* 32x speed or faster CD-ROM drive.
* 64 MB shader-capable video card.
* A sound card and either a set of speakers or a set of headphones are required for audio.
* A Microsoft Mouse or compatible pointing device.
If you didn't know already, to check your comp's specs go to start and look for run. Once you've clicked run, type 'dxdiag' in the search box and hit OK.
If you've already gone and checked your specs then I don't know what else to tell ya. It might also help if you post what the error box says, because other peeps might be able to help you out further.